The tripeptideN-Cbz-βGly-Gly-Gly-Obz

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The tripeptide N-Cbz-βGly-Gly-Gly-Obz

The title peptide, N-benzyl-oxycarbonyl-β-glycylglycylglycine benzyl ester, C22H25N3O6, contains a non-proteinogenic amino acid residue, β-glycine, which is a homologated analogue of glycine. In the mol-ecular structure, β-glycine adopts an extended conformation with a trans conformation about its C(β)-C(α) bond. The second glycine residue adopts an extended conformation while the third glycine...

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Infrared Spectroscopy of Mobility-Selected H+-Gly-Pro-Gly-Gly (GPGG).

We report the first results from a new instrument capable of acquiring infrared spectra of mobility-selected ions. This demonstration involves using ion mobility to first separate the protonated peptide Gly-Pro-Gly-Gly (GPGG) into two conformational families with collisional cross-sections of 93.8 and 96.8 Å(2). After separation, each family is independently analyzed by acquiring the infrared p...

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Enzymic methylation of arginyl residues in -gly-arg-gly- peptides.

N(G)-Methylation of arginine residues in many nucleic-acid-binding proteins are formed post-translationally, catalysed by S-adenosylmethionine:protein-arginine N-methyltransferase in their glycine-rich and arginine-rich motifs. The amino acid sequences of the stimulator of HIV-1 TAR (Tat-responsive element) RNA-binding protein (SRB) and fibronectin also show the presence of the internal -Gly-Ar...

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Radiation chemical studies of Gly-Met-Gly in aqueous solution.

Important biological consequences are related to the reaction of HO• radicals with methionine (Met). Several fundamental aspects remain to be defined when Met is an amino acid residue incorporated in the interior of peptides and proteins. The present study focuses on Gly-Met-Gly, the simplest peptide where Met is not a terminal residue. The reactions of HO• with Gly-Met-Gly and its N-acetyl der...

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Oligopeptides with the sequences ala-pro-gly and gly-pro-gly as substrates or inhibitors for protocollagen proline hydroxylase.

Sequential oligopeptides prepared by condensation of peptides with the sequence Ala-Pro-Gly or Gly-Pro-Gly were examined as possible substrates or inhibitors for the synthesis of hydroxyproline by protocollagen proline hydroxylase. The tripeptide BOC-Ala-Pro-Gly-OMe (where BOC-represents 1-butoxycarboxyland Me represents methyl) was not hydroxylated, but oligopeptides ranging in size from BOC(A...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section E Crystallographic Communications

سال: 2015

ISSN: 2056-9890

DOI: 10.1107/s2056989015004272